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359916

Serum Epidermal Growth Factor Level and its Relation to Severity of Alopecia Areata

Article

Last updated: 29 Dec 2024

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Tags

Clinical Biochemistry

Abstract

 Background: Epidermal growth factor (EGF) is a growth factor that plays an important role in the regulation of cell growth, proliferation, and differentiation by binding to epidermal growth factor receptor (EGFR). The roles of EGF and EGFR in the pathogenesis of alopecia areata (AA) are uncertain. However, several reports suggest an association between EGF signaling and AA.
Objective: To estimate the serum level of EGF in patients with Alopecia Areata and its correlation with disease severity.
Patients and Methods: This is a case-control study, was conducted at the outpatient clinic in Beni-Suef University Hospital, on Sixty persons divided into 2 groups: (Group A): included 30 patients having alopecia areata, (Group B): included 30 apparently healthy age- and sex-matched individuals as controls, from January 2020 to July 2022.
Results: There was a strong correlation between EGF and SALT scores with high significance.
Conclusion: The EGF is significantly elevated in AA patients compared to the control subjects. It is also positively correlated with the disease's number and extent, making it a possible marker of AA severity. High levels of EGF are present in patients with AA and positively correlate with severity, which may indicate a causal role of EGF in the pathogenesis of AA. 

DOI

10.21608/ijabmb.2024.359916

Keywords

Alopecia Areata, EGF

Authors

First Name

Abd-El Aziz Ibrahim

Last Name

El-Taweel

MiddleName

-

Affiliation

Department of Dermatology, Faculty of Medicine, Benha University, Benha, Egypt

Email

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City

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Orcid

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First Name

Radwa Ibrahim Muhammad Muhammad

Last Name

El Metwally

MiddleName

-

Affiliation

Department of Dermatology, Mansoura Dermatology Hospital, Mansoura, Egypt

Email

-

City

-

Orcid

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First Name

Sara Mahmoud

Last Name

Hassan

MiddleName

-

Affiliation

Department of Clinical, and Chemical Pathology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.

Email

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City

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Orcid

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First Name

Hanan Abd El-Razek

Last Name

Kamel

MiddleName

-

Affiliation

Department of Dermatology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt

Email

-

City

-

Orcid

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Volume

1

Article Issue

1

Related Issue

48441

Issue Date

2024-01-01

Receive Date

2024-06-10

Publish Date

2024-01-01

Page Start

16

Page End

31

Print ISSN

3009-7630

Online ISSN

3009-7991

Article File

IJABMB_Volume 1_Issue 1_Pages 16-31.pdf

PDF . 457.1kB

Link

https://ijabmb.journals.ekb.eg/article_359916.html

Detail API

https://ijabmb.journals.ekb.eg/service?article_code=359916

Order

359,916

Type

Original Article

Type Code

3,170

Publication Type

Journal

Publication Title

International Journal of Applied Biochemistry and Molecular Biology

Publication Link

https://ijabmb.journals.ekb.eg/

MainTitle

Serum Epidermal Growth Factor Level and its Relation to Severity of Alopecia Areata

Details

Type

Article

Created At

21 Dec 2024