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359914

Role of Neurofilament Light Chain in Relapsing Remitting Multiple Sclerosis Patients

Article

Last updated: 29 Dec 2024

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Tags

Clinical Biochemistry
Molecular Biology

Abstract

 Background: Neurofilament light chain (NfL) is released from damaged neurons and elevated levels in the blood reflect ongoing neuroaxonal injury in multiple sclerosis (MS). Assessing NfL levels could provide insight into disease activity and treatment responses in MS patients.
Objective: To investigate the relationship of plasma NfL levels with clinical and MRI parameters and disability scores in relapsing-remitting MS (RRMS) patients.
Patient and method: Plasma NfL concentrations were measured by ELISA in 42 RRMS patients in remission and 42 healthy matched controls. Associations with demographics, disease characteristics, MRI lesion counts, and Expanded Disability Status Scale (EDSS) scores were analyzed.
Results: RRMS patients had significantly higher NfL levels than controls (p=0.009). Levels were lower in treated vs untreated patients (p<0.001) and correlated positively with age, disease duration, relapse numbers, T2-lesion burden, and EDSS scores (p<0.05). No correlation was observed with the recent relapse rate or treatment duration.
Conclusion: Increased plasma NfL levels were associated with greater disability in RRMS patients and were lowered by treatment, indicating potential neuroprotective effects. NfL could be a useful biomarker in monitoring subclinical disease activity and treatment responses longitudinally. 

DOI

10.21608/ijabmb.2024.359914

Authors

First Name

Mohammed Mabrouk

Last Name

Masoud

MiddleName

-

Affiliation

Neurology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt

Email

-

City

-

Orcid

-

First Name

Rasha Hasan

Last Name

Soliman

MiddleName

-

Affiliation

Neurology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt

Email

-

City

-

Orcid

-

First Name

Ahmed Nabil

Last Name

Senousy

MiddleName

-

Affiliation

Neurology Department, Elsahel Teaching Hospital, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Nesreen Mostafa

Last Name

Kamel

MiddleName

-

Affiliation

Clinical and Chemical Pathology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.

Email

-

City

-

Orcid

-

First Name

Noha Ali Abd

Last Name

Elmonem

MiddleName

-

Affiliation

Neurology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt

Email

-

City

-

Orcid

-

Volume

1

Article Issue

1

Related Issue

48441

Issue Date

2024-01-01

Receive Date

2024-06-10

Publish Date

2024-01-01

Page Start

1

Page End

14

Print ISSN

3009-7630

Online ISSN

3009-7991

Article File

IJABMB_Volume 1_Issue 1_Pages 1-14.pdf

PDF . 290.9kB

Link

https://ijabmb.journals.ekb.eg/article_359914.html

Detail API

https://ijabmb.journals.ekb.eg/service?article_code=359914

Order

359,914

Type

Original Article

Type Code

3,170

Publication Type

Journal

Publication Title

International Journal of Applied Biochemistry and Molecular Biology

Publication Link

https://ijabmb.journals.ekb.eg/

MainTitle

Role of Neurofilament Light Chain in Relapsing Remitting Multiple Sclerosis Patients

Details

Type

Article

Created At

21 Dec 2024