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358642

Investigation of immunomodulatory role of honey on cisplatin injected rats

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Last updated: 21 Dec 2024

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Abstract

The aim of the present study is to evaluate the role of honey as an immunomodulator. Rats given cisplatin injections as immune suppressor agent were used to study the effect of honey as an immunological modulator. Cisplatin treatment resulted in a reduction in WBCs and neutrophil counts, antibodies IgG and IgM, as well as Bcl2 gene expression levels an increase in IL-4 and IL-6 levels, BAX and iNOS gene expression levels, and notable histological alterations in spleen tissue sections, including the expansion of the red pulp with lymphocytic depletion and many variable-sized blood-filled voids. All study parameters are successfully improved by the co-administration of honey and cisplatin. The results obtained can be explained by the high concentration of bioactive compounds in honey, including phenolic acids and flavonoids. Therefore, honey can modulate the immune system. In conclusion, honey can mitigate the damaging effects that cisplatin has on the immune system.

DOI

10.21608/astb.2023.358642

Keywords

Honey, CIS Platin, Immune system, GC-MS

Volume

1

Article Issue

1

Related Issue

48256

Issue Date

2023-12-01

Receive Date

2024-06-05

Publish Date

2023-12-01

Page Start

38

Page End

56

Print ISSN

1110-0184

Online ISSN

3009-7916

Link

https://astb.journals.ekb.eg/article_358642.html

Detail API

https://astb.journals.ekb.eg/service?article_code=358642

Order

358,642

Type

Original Article

Type Code

3,140

Publication Type

Journal

Publication Title

Aswan Science and Technology Bulletin

Publication Link

https://astb.journals.ekb.eg/

MainTitle

Investigation of immunomodulatory role of honey on cisplatin injected rats

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Type

Article

Created At

21 Dec 2024