Beta
ManageSearchChatDiscover
396001

Molecular and histopathological studies on commercial vaccines against H9 avian influenza in broilers

Article

Last updated: 21 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Avian /Rabbit diseases

Abstract

Avian influenza virus is one of the major threats that has been affecting the poultry industry in the Middle East region for decades. Many trials were made to eradicate the disease, but it doesn't work. Nowadays, there are many commercial vaccines that are either imported or prepared from circulating isolates from H9N2 in Egypt and Middle Eastern countries. This study focused on understanding the effectiveness of five commercial vaccines for their ability to give protection. Six groups of one day-old broiler chicks (n=15) were placed under normal conditions in separate pens. Each group was immunized with the specific vaccine at 4th day of age and then they were challenged with H9N2 virus at 14 days old. After challenge, respiratory signs, swelling of head, reduction in the feed consumption rate, decrease in the average body weight and general depression were observed. Postmortem findings of the euthanized birds revealed congestion of lung, tracheitis, swelling of kidneys and inflammation of bursa of fabricius. On histopathological examination, bursa of Fabricius shows different lesions of interfollicular edema, lymphocytic depletion, necrosis and sloughing of lymphoid cells which illustrates the immunosuppressive effect of the virus. The unvaccinated challenged group sheds the highest titer (mean 104.7 EID50/ml) while the remaining vaccinated groups sheds lowest titer (mean 101 - 104 EID50/ml). The vaccinated birds show less signs of disease, less degree of pathological lesions and lower viral shedding titer. This explains the importance of using H9N2 different inactivated vaccines in poultry farms for controlling the spread of the disease

DOI

10.21608/ijcvr.2024.326923.1005

Keywords

Avian influenza, H9N2, vaccine, challenge, broiler

Authors

First Name

H.

Last Name

Asaad

MiddleName

M.

Affiliation

Poultry diseases department, Faculty of Veterinary Medicine, Sohag University, Sohag, Egypt

Email

hemavet92@yahoo.com

City

Sohag, Egypt

Orcid

-

First Name

O.

Last Name

Hassanin

MiddleName

-

Affiliation

Avian and Rabbit Medicine Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt

Email

olahassanin@zu.edu.eg

City

-

Orcid

-

First Name

M.

Last Name

Saif-Edin

MiddleName

E.

Affiliation

Avian and Rabbit Medicine Department, Faculty of Veterinary Medicine, Assiut University, Asyut, Egypt

Email

msaifedin@aun.edu.eg

City

-

Orcid

-

First Name

R.

Last Name

Ibrahim

MiddleName

S.

Affiliation

Avian and Rabbit Medicine Department, Faculty of Veterinary Medicine, Assiut University, Asyut, Egypt

Email

ragab@aun.edu.eg.com

City

-

Orcid

-

First Name

M.

Last Name

Mohamed

MiddleName

A.

Affiliation

Avian and Rabbit Medicine Department, Faculty of Veterinary Medicine, Assiut University, Asyut, Egypt

Email

moemenmohamed@aun.edu.eg

City

-

Orcid

-

First Name

Mustafa

Last Name

Hamad

MiddleName

-

Affiliation

Veterinarian at Sohag Veterinary Medicine Directorate

Email

mostafa.hamad@vet.au.edu.eg

City

-

Orcid

-

First Name

M.

Last Name

Hamed

MiddleName

G.

Affiliation

Pathology and Clinical Pathology department, Faculty of Veterinary Medicine, Sohag University, Sohag, Egypt

Email

mohamed.gamal@vet.sohag.edu.eg

City

-

Orcid

-

First Name

Sary

Last Name

Abd-Elghaffar

MiddleName

Kh.

Affiliation

Pathology and Clinical Pathology department, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt

Email

sarynasr@aun.edu.eg

City

-

Orcid

-

First Name

T.

Last Name

Abdullatif

MiddleName

M.

Affiliation

Avian and Rabbit Medicine Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt

Email

tamermahmoudpoul2016@gmail.com

City

-

Orcid

-

Volume

2

Article Issue

2

Related Issue

49198

Issue Date

2024-12-01

Receive Date

2024-10-08

Publish Date

2024-12-01

Page Start

30

Page End

39

Print ISSN

3009-7940

Online ISSN

3009-6251

Article File

IJCVR_Volume 2_Issue 2_Pages 30-39.pdf

PDF . 846.5kB

Link

https://ijcvr.journals.ekb.eg/article_396001.html

Detail API

https://ijcvr.journals.ekb.eg/service?article_code=396001

Order

396,001

Type

Original Article

Type Code

3,135

Publication Type

Journal

Publication Title

International Journal of Comprehensive Veterinary Research

Publication Link

https://ijcvr.journals.ekb.eg/

MainTitle

Molecular and histopathological studies on commercial vaccines against H9 avian influenza in broilers

Details

Type

Article

Created At

21 Dec 2024