Background: Liver cirrhosis is characterized as the advanced phase of liver scarring resulting from various liver diseases and conditions, such as hepatitis and prolonged alcohol abuse. Aim of the study : Asses' nurses' performance regarding management for patient with advanced stage liver cirrhosis. Research Design: A descriptive exploratory design was utilized. Setting: This study was carried out in ICU 1 (Endemic) and ICUs 2 and 3 at Beni-Suef University Hospital.. Study subjects: convenient sample of all available nurses (50) were included in the study. Data collection tools: Data were obtained through nurses" knowledge questionnaire, nurses' observational checklists and Likert rating scale for nurses' attitude Result: It's found that 72% of studied nurses had unsatisfactory level of knowledge regarding management for patients with advanced stage liver cirrhosis and 70% of the studied nurses had unsatisfactory level of practice . Meanwhile, 66% of the nurses under the study had negative attitude Conclusion: less than three quarters of studied nurses had unsatisfactory level of knowledge . Meanwhile, less than three quarters studied nurses had unsatisfactory level of practice . less than two thirds of the nurses under study had negative attitude . There was statistically significant correlation between knowledge, attitude and practice among the studied nurses P<0.05. Recommendations: Designing In-service training and educational program to Improve nurses' knowledge and practice regarding advanced stage liver cirrhosis . The study should be replicated on large sample and In different hospitals setting In order to generalize the results.