The use of glue and particularly histoacryl in different branches of medicine and surgery has been explored. Its role and 
use in general and different branches of surgery is very wide. Its role to minimize the surgical procedure time and production of cosmetic effect is now accepted. This study was done to define and evaluate the tissue response to histoacryle as glue in fixation of anterior abdominal wall mesh in hernia repair i.e. its patho-histological effect. So we will be able to apply it in human safely. 30 mice were used and proline meshes were applied and fixed with histoacryl to the anterior abdominal wall. 
They were all sacrificed and the abdominal walls were fixed in formaline and histopatological and immunohistochemestry studies were done. We found that all our specimens had primary union healing with first intention in the skin incision and in the deeper tissue were the mesh lies no complications were found in our study in relation to the method of fixation.