Surgical removal of the spleen is a well established procedure which is indicated for various Hematologic disorders. As 
an alternative to surgical splenectomy, partial splenic embolization was done on 21 patients for secondary hypersplenism due to portal hypertension, manifested by splenomegaly, thrombocytopenia, leucopenia, and erythrocyte hemolysis. Within few days platelet and leucocytic counts rose significantly in all patients, and were maintained throughout the whole follow up period, hemoglobin levels did not significantly changed immediately after PSE, but returned to normal levels by 6 months after PSE. Splenic volume was decreased significantly after PSE. Transient procedural complications included abdominal pain and fever in all patients, 2 patients developed left basal pneumonia, and 2 patients developed bleeding from the puncture site. Given the safety, efficacy, and advantages of PSE, it should be considered a valid alternative treatment of hypersplenism and the treatment of choice for selected patients with hypersplenism caused by PHT.