Background: After splenectomy, patients have an increased risk of overwhelming infection. The value of human spleen 
autotransplantation after splenectomy because of trauma has long been questioned. The aim of this work is to study 
(experimental and applied) the effect of partial splenic autotransplantation (PSA) on haematological changes and some 
immunological splenic functions. 
Methods: The present study was conducted on 45 patients and 60 rabbits divided into groups underwent either total 
splenectomy only, total splenectomy with intraperitoneal partial splenic autotransplantation (IPPSA) or total splenectomy 
with extraperitoneal partial splenic autotransplantation (EPPSA). Another group of 15 rabbits underwent total splenectomy with intramuscular partial splenic autotransplantation (IMPSA). Haematological changes and serum immunoglobulins (IgM, IgA, IgG) were studied on days 1, 30 and 90 postoperatively. 
Results: Both experimental and applied groups underwent PSA showed preservation of the splenic immunological functions and insignificant haematological changes irrespective of the site of autotransplantation. The vascularity of the 
autotransplanted splenic slices depends on the optimum size of the slice, (5 mm in thickness). 
Conclusion: With extensive splenic trauma, total splenectomy with PSA can be performed safely with insignificant 
haematological changes and preservation of splenic immunological functions.