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374508

HISTOPATHOLOGICAL ASSESSMENT OF THE EFFECT OF NONABSORBABLE PROSTHETIC MESH ON THE SPERMATIC CORD CONTENTS: AN EXPERIMENTAL STUDY

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Last updated: 29 Dec 2024

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Abstract

Background: Previous studies have documented that the use of synthetic prosthesis in repair of inguinal hernia 
markedly reduces the incidence of recurrence. However, little is known about the effect of these prostheses on the spermatic cord contents. This work was carried out to study the histopathological changes in response to contact with the commonly used prostheses (Prolene & Mersilene) on spermatic cord contents in male dogs. 
Materials and Methods: Thirty two male dogs were included in this study. The spermatic cords and testes were harvested from 2 dogs as a base line for the normal histology. The remaining 30 dogs were divided into 3 main groups. In the first (control) group (G1,n=10), the spermatic cord was delivered, its coverings were dissected and left intact on one side but on the other side it was skeletonized by removing its coverings. In the second group (GII,n=10), a strip of polypropylene (Prolene) mesh was wrapped snugly without strangulation around the dissected intact cord on one side and the skeletonized cord on the other side. A polyester (Mersilene) mesh was similarly applied in the third group (GIII,n=10). In each group, the spermatic cords and testes were examined histopathologically one week, and three months postoperatively. 
Results: At one week, the microscopic examination of the spermatic cord contents revealed more acute inflammatory reaction in mesh groups than the control. This reaction considerably subsided after three months with varying degrees and patterns of fibrous tissue deposition. These changes were more noticed in GIII than GII and in skeletonized cords than intact ones. The testes of all animals showed no histopathological changes. 
Conclusion: This experimental study proved the safety of the used non-absorbable prostheses on the spermatic cord contents and testes. Prolene mesh without skeletonization of the cord revealed more favorable results than Mersilene one.

DOI

10.21608/ejsur.2003.374508

Keywords

Mesh, prolene, Mersilene, testis, Spermatic cord, histopathology

Authors

First Name

Mohamed

Last Name

Abbas

MiddleName

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Affiliation

Departments of General Surgery, Theodor Bilharz Research Institute (TBRI), Giza

Email

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City

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Orcid

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First Name

Zeinab

Last Name

Omran

MiddleName

-

Affiliation

Pathology, Theodor Bilharz Research Institute (TBRI), Giza.

Email

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City

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Orcid

-

First Name

Mona

Last Name

Nosseir

MiddleName

-

Affiliation

Pathology, Theodor Bilharz Research Institute (TBRI), Giza.

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Volume

22

Article Issue

3

Related Issue

49843

Issue Date

2003-07-01

Receive Date

2024-08-18

Publish Date

2003-07-01

Page Start

223

Page End

231

Print ISSN

1110-1121

Online ISSN

1687-7624

Link

https://ejsur.journals.ekb.eg/article_374508.html

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https://ejsur.journals.ekb.eg/service?article_code=374508

Order

374,508

Type

Original Article

Type Code

3,086

Publication Type

Journal

Publication Title

The Egyptian Journal of Surgery

Publication Link

https://ejsur.journals.ekb.eg/

MainTitle

HISTOPATHOLOGICAL ASSESSMENT OF THE EFFECT OF NONABSORBABLE PROSTHETIC MESH ON THE SPERMATIC CORD CONTENTS: AN EXPERIMENTAL STUDY

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Article

Created At

21 Dec 2024