Aim: to study the effect of full thickness excision off the inferiorly based flap. 
Methods: Reduction mammaplasty by the inferior pedicle technique used in two equal groups of 30 patients, 1st. group the flap based on dermoglandular tissue, 2nd. Group the flap based on glandular tissue only with excision of full thickness skin off the flap. 
Results: Concerning the aesthetic results and complications there is no significant differences between the two groups. A comparative study between the two groups revealed that the retained dermis does not improve the vascularity of the nipple and areola but the operative time showed marked difference, in the first group (dermoglandular pedicle), the mean operative time was 207 minutes while in the second group (glandular pedicle) the mean operative time was 130 minutes. 
Conclusion: Reduction mammaplasty by the inferior pedicle technique is versatile, safe and easy. Full thickness excision of the skin from the inferior pedicle save the time, avoid possibility of post-operative inclusion dermoid cyst formation and reduced anesthesia time without any effect on the breast projection and viability of the nipple areola complex.