Aim: Helicobacter pylori (H.Pylori) plays a fundamental role in the causation of duodenal ulcer. This study was conducted to elucidate the prevalence of H.Pylori in patients with a perforated duodenal ulcer and to determine whether eradication of H.Pylori prevent ulcer recurrence following simple repair of the perforation. 
Methods: Eighty three patients admitted with perforated duodenal ulcer, only seventy seven patients treated with simple 
closure included in our study. Sixty five patients (84.4 %) who had H.Pylori infection were randomly divided into triple 
therapy group (34 patients) and alone group (31 patients). Follow up endoscopy was performed at 8 w, 16 w and 1 year to show the ulcer healing and determine H.Pylori. 
Results: The eradication of H.Pylori was significantly higher in triple therapy group than omeprazole alone group (at 8 weeks 91.2% vs. 22.6% respectively). Initial healing of ulcer was significantly better in eradication group and after one year the difference in ulcer recurrence between the two groups was statistically significant (2 (6.1%) in eradication group vs. 8 (29.6%) in omeprazole alone group P=0.001). 
Conclusion: H.Pylori was present at a high ratio in patients with duodenal ulcer perforation. Eradication of H.Pylori after 
simple closure of a perforated duodenal ulcer reduces the incidence of recurrent ulcer.