Aim: The purpose of this study was to determine the Incidence of Helicobacter Pylori infection in patients 
with laryngopharyngeal reflux disease and whether the severity of symptoms in positive H. pylori patients 
is different than negative H. pylori patients.
Laryngopharyngeal Reflux Disease (LPRD) implies a backward of part of the stomach contents up the 
throat. The literature has reported a relationship between reflux esophagitis with Helicobacter pylori 
infection but not yet with reflux laryngitis. 
Methods: 483 patients with atypical symptoms of LFRD were subjected to laryngoscopic evaluation, 
ambulatory 24 hours pH monitoring and HpSA test. 
Results: an incidence of HpSA positive test was 64% among the study population.
There is no significant difference between hoarseness of voice, chronic unexplained cough, feeling of a lump 
in throat, frequent throat clearing, bad/bitter taste in mouth with HpSA test results. Also there was no 
significant difference between the mean intensity, frequency and indices of the symptoms with the HpSA 
test results
Conclusion: The incidence of the H. pylori infection in patients with LFRD in our study was 64%, statistical 
analysis did not reveal significant difference in symptom severity among patients, the questionable role of H 
pylori infection is discussed.