Aim: To evaluate patients with gall bladder carcinoma to define the demographics, modes of presentations,
clinical staging, pathological characters and survival.
Methods: A retrospective study on 80 patients with gall bladder carcinoma at Gastroenterology Surgical 
Center, Mansoura University between 1990 to 2012. There were 45 males & 35 females with an average age of 
53 years. Patients were classified according to the mode of presentation into four groups and the treatment 
modalities were according to presentation, state of the tumor & associated liver condition. All patients were 
followed up by ultrasound (or CT) every 6 months postoperatively. Survival was monitored with respect to 
the histological type of the tumor & stage of the disease.
Results: Gall bladder carcinoma represented 1.3% of a total of 5980 cases of abdominal malignancies in our 
center. HCV infection was present in 15% and associated gall stones in 45% of patients. We had 40 (50%) 
patients with gall bladder mass or obstructed gall bladder, 23 (28.75%) with symptomatic gall stones, 15 
(18.75%) with obstructive Jaundice and 2 (2.5%) with gastrointestinal bleeding. Extended cholecystectomy 
done in 32 (4o %) patients but nothing done for 26 (32.5%) patients due to advanced tumor . Right 
hepatectomy was done for 12 (15%) patients due to infiltration of right liver lobe & right hepatic duct. 
Laparoscopic cholecystectomy was done for 8 (10%) patients as tumour was discovered accidentally. 
Extended cholecystectomy plus right hemicolectomy for one patient & for the last patient extended 
cholecystectomy was done with pancreaticodudenectomy. Survival was from 8-43 months according to line of 
treatment, but 5 year- survival was zero percent.
Conclusion: Gall bladder carcinoma is not uncommon with poor prognosis. Prevention is important & routine 
postoperative histopathology is mandatory.