Summary Background Data: Feasibility of laparoscopic repair of the abdominal wall defects have been 
widely documented and showing good characteristics in terms of a reduction of morbidity, postoperative 
pain, intervention times and hospitalization, a reduction of wound complication and a further reduction of 
recurrences.
Objective: The aim of this study was to determine the best intraperitoneal mesh material and the best fixing 
device for laparoscopic repair of abdominal wall defects and, secondly, to verify its feasibility and safety.
Materials and methods: The tests were carried out on 5 pigs, in accordance with all international laws, ethics, 
regulations and quality criteria. In each pig we positioned 5 different meshes in each hemi-abdomen (Parietex, 
Hi-Tex, Proceed, Composix and Goretex) and fixing them with 5 different fixing devices (Tissucol, Glubran, 
Quixil, EMS and Protack). We carried out a laparoscopic second look at 15 and 30 days, and biopsies were 
taken for histological analysis and strength tests after pig's suppression.
Results: No intra-operative and post-operative complications were observed. The best mesh material resulted 
to be Parietex, Composix and then Hi-Tex, with the best reperitonalization, no adhesions, no shrinkage, no 
migration of the mesh and good tensile strength. Histopathological analysis confirmed a greater stability and 
great tissue integration.
Conclusion: This study showed that the best intraperitoneal prosthetic materials for laparoscopic repair of 
abdominal wall defects were Parietex, Composix and Hi-Tex, with the use of Tissucol and Quixil as fixing 
devices for the prosthesis.