Intussusception is a rare cause of intestinal obstruction in adults and is usually secondary to malignant neoplasms as the pathologic leading point. We present a case of ileocolic intussusception in an adult caused by a large pedunculated cecal lipoma and mobile cecum. The patient was a 45-year-old woman with 3 weeks’ history of colicky abdominal pain, hematochezia, and alternating bowel habits. Computed tomography of the abdomen revealed ileocolic intussusception with 7×5 cm low-density mass in the cecum. Right hemicolectomy was performed, and histopathological examination of the specimen confirmed the diagnosis of a subserosal cecal lipoma.