Introduction: Constipation is a common problem among patients who are taking antipsychotic medication, there is a
strong association between the use of risperidone and megacolon but the exact mechanism behind this has not established yet.
Case Report: We present a case of megacolon associated with the long-term use of antipsychotic medication, this patient
needs surgical intervention to resolve the problem.
Discussion/Conclusion: Constipation and related complications represent a problem among psychotic patients who are
taking antipsychotic medications, especially the older groups, more studies are needed to identify the exact relation that
could be related to the disease itself or the use of a specific kind of medicine.