Purpose
To evaluate the association of various metabolic risk factors with percent mammographic breast density (PMD), and to assess the advantage of screening mammogram in type 2 diabetes mellitus (T2DM) postmenopausal diabetic women.
Patients and methods
This was a cross-sectional study which included 90 postmenopausal women, who were divided into two groups: group I included 60 patients diagnosed with T2DM and group II included 30 controls.
Results
There was significant inverse associations between PMD and weight (=0.006, 0.022, 0.010), BMI (=0.003, 0.015, 0.001), and waist circumference (=0.001, 0.019, 0.001) in cases, control, and total sample, respectively. After adjustment for weight in the total sample, the extremely dense group (breast imaging-reporting and data system D) was only associated with age of menarche (odds ratio, 0.404), while in cases group, breast imaging-reporting and data system D was only significantly associated with waist circumference (odds ratio, 0.756).
Conclusions
PMD levels were not increased in the presence of multiple metabolic risks, pointing to an alternative pathway explaining the increased risk of cancer breast in T2DM postmenopausal women.