One of the cause's insulin patients are sent to clinics is diabetic foot ulcers (DFU), and
when this happens, empirical antibiotic therapy is required. In order to evaluate the bacteriological
profile and susceptibility pattern of these infections, we undertook a retrospective study of patients
with DFU who needed hospitalization. We evaluated 100 patients were collected over a period of 5
months starting from October, 2018 until March 2019 on patients attending the outpatient clinic of
diabetic foot unit, Zefta Hospitals, Gharbay, Egypt. The bacteria were isolated from different age,
from 62 male there age ranged from 45 to 70 years and from 38 female there age ranged from 40 to
65 years. Gram-positive bacteria were responsible for 52.8% of the isolates, while Gram-negative
were responsible for 47.2%. Staphylococcus aureus was the most prevalent pathogen, followed by
Escherichia coli. Regarding the susceptibility profile, we found all bacterial strains were sensitive
to IPM, except Pseudomonas aureginosa was resistant. IPM was the effective antibiotics against all
Gram positive bacteria. All isolates of P. aeruginosa resistant to IPM and susceptible to antibiotics
AK, CN. Our result shows S. aureus was susceptible to antibiotics AK, IPM with 100%. The E. coli
was susceptible to antibiotics IPM with 100%. Information of microbiological profile and
antibiotics susceptibility of patients with DFU is useful to evidence clinical therapy.