Hepatocellular carcinoma (HCC) is the most common primary liver cancer worldwide. This study was performed to
explore the effect of low dose γ-irradiation (LDR) and Combretastatin A-4 disodium phosphate (CA-4DP) on HCC induced
by N-nitrosodiethylamine (NDEA) in rats.
Male Wistar albino rats were orally administrated NDEA for 17 weeks. Rats bearing HCC were intravenously injected with
10 mg/kg of CA-4DP and/or exposed to 0.20 Gy of γ-irradiation. Histopathological examination of the liver tissues was
performed following 6, 24, and 48 h post CA-4DP injection.
Treatment with LDR and CA-4DP resulted in extensive bleeding and necrosis in tumor tissue that was associated with
HCC regression. The presented study demonstrated the promising therapeutic advantage of LDR along with CA-4DP in
HCC.