Background: Since nurses make up the majority of hospital employees, having an adequate number of qualified nurses on staff is crucial for providing high-quality treatment. Mastering clinical nursing techniques promotes a successful and self-assured nursing professions in addition to raising the standard of patient care overall. In the realm of medicine and healthcare, extended reality (XR) is a revolution. The use of extended reality technology in medical professional education has gained traction. Using XR in practice made the students feel as though they were actually in a clinical setting. Aim: this study aimed to evaluate the efficacy of an educational program on extended reality knowledge among Damietta University nursing students. Design: Quasi-experimental design (one group pre / post-test) was utilized in the current study. Sample: A purposive samples of 40 undergraduate nursing students at level four was selected. Setting: The study was implemented at Faculty of Nursing -Damietta University. Methods: one method for data collection was used; a Google form questionnaire was applied to collect data pertinent to the study. Results: a highly statistically significant difference between total score knowledge among undergraduate nursing students in pre and post-tests. Conclusion: the current study revealed the effect of the educational program on changing nursing students' knowledge regarding XR to higher score level. Recommendation: design specialized health education sessions by integration with Faculty of Computer and Artificial Intelligence to upgrades nursing students' knowledge with EX applications.