Nurses who work in addiction treatment facilities have a very difficult job. They invest time and energy into patients who may relapse repeatedly before treatment gains a foothold. Aim of the study: This study aimed to evaluate the effect of a psycho-educational program on nursing staff caring behavior skills towards patients having substance related disorders. Methods: A quasi-experimental design was used. The subjects of the study included 134 nurses and divided into (Experimental group & Control group) with 67 nurses in each group who were chosen by purposive sampling. The study was conducted at Benha Mental Health and Addiction Hospital. Tools for data collection: two tools were used for data collection; Tool (1): Questionnaire interview assessing nursing staff socio-demographic data, Tool (2): Caring Behavior Assessment Tool adapted to assess nursing staff' perception regarding caring behavior skills toward substance related disorder patients. Results: there was statistically significant improvement in the studied nurses' caring behavior skills toward substance related disorder' patients after implementation of a psycho-educational program. Conclusion: it was concluded that, the psycho-educational program had a positive effect on the nursing staff caring behavior skills towards patients having substance related disorder. Recommendations: The study suggested that providing up-to-date educational  and training programs on regular basis for nurses' dealing with patients having substance related disorders about new health issues and its trends related to these disorders.