The main purpose of this study is to detect the alteration minerals at Gabal Dara area, which is considered one of the most important area sat the eastern desert in Egypt for radioactive exploration. Gamma ray spectrometry and remote sensing ASTER data were processed and analyzed for mapping the mineralization zones in the area. In Gabal Dara area, younger granite was considered as a mapping target due to the high concentration of radioactive materials as indicated from gamma ray spectrometry data. Advanced Space borne Thermal Emission and Reflection Radiometer(ASTER) L1B imagery was used for mapping the alteration mineral zones such as phyllic, argillic and propylitic mineral assemblages. Feature-oriented principal component selection (FPCS) was imposed at ASTER VNIR-SWIR spectral bands with the objective of mapping the occurrence of mineral and members related to hydrothermal alterations in Gabal Dara. The constructed alteration maps show good coincidence with the explored mineral resources and suggest further similar unexplored sites. These maps can be used as a guide for further follow-up radioelement and mineral exploration works in the area.