The construction of Wadi El Natrun- Al Alamain Road has created a new accessible desert area aimed for development that is based mainly on its local groundwater resources. Unfortunately little is known about the groundwater setting of the area on both sides of the road. A total of 31 Vertical Electrical Soundings (VES) were carried out to reveal the groundwater setting of the area. Interpretation of the VES curves indicated a sedimentary succession of 5 layers, the 4th layer downward of which is the water-bearing formation. The depth to top of that layer varies from 46 to 116 m, its thickness ranges from 10 to 29m, while its electrical resistivity is in the range of 12 to 31 Ohm.m. Based on the interpreted results, 6 cross sections and 4 contour maps were constructed to present these results. Based on these results, together with the previous regional and local data available for the area, a groundwater potential map was further constructed showing the ranking of water potential across the area. Recommended sites for the drilling of water wells were also pointed out with the specifications of each of these sites, as well as the precautions that should be taken during drilling and use of these wells