Risk analysis process is controlled by three main parameters which are the earthquake hazard, vulnerability and economic asset. The first parameter can not be controlled and based mainly on the tectonics and seismicity of the area and its surroundings. The second and third parameters are based on man's education, knowledge and experience. So, they are controlled and hence they play a role in reduction of generated risk. Cairo lies at the intersection of two main seismo-tectonic trends; North Red Sea-Gulf of Suez-Cairo-Alexandria Clysmic trend and East Mediterranean-Cairo Fayum Pelusiac trend. The seismo-tectonic model governed the greater Cairo and its surroundings has been constructed consisting of three main seismo-tectonic provinces which are named East Mediterranean, West Mediterranean and Fayum seismo-tectonic source zones. The expected hazard in the form of peak ground acceleration with 90% probability of not being exceeded through 50, 100 and 200 year exposure times has been estimated. The maps show high ground acceleration in the northern and eastern parts compared with the southern and western parts. This means that the buildings and facilities located in the northern and eastern areas of Cairo may be subjected to high vibratory ground motion values compared to the southern and western parts. So, the buildings in the northern and eastern parts should be characterized by low vulnerability and low economic assest to minimize the net risk. Meanwhile, the critical and high risk buildings should be located in the southern and western parts.