Otosclerosis is the abnormal growth of bone of the middle ear affects endochondral bone of the otic capsule that prevents structures within the ear from working properly and causes hearing loss. To assess the radiological findings in patients with otosclerosis using high-resolution multislice computed tomographic (CT) scan. This prospective study was done at Assiut University hospital during the period from June 2016 to August 2017. Thirty patients were enrolled in this study; 11 (36.7%) males and 19 (63.3%) females. CT was efficient in the diagnosis of otosclerotic foci, showing a high rate of positivity. The multislice CT findings were bilateral in 45 ears and this evidence was statistically significant. Preoperative high-resolution CT scan may serve as a valuable imaging method in the planning of stapes surgery. It helps to avoid serious complications and unnecessary stapes surgeries by the detection of several abnormalities in the middle or inner ear CT density of otosclerotic lesions in any of the CT grades was significantly correlated with hearing loss.