Currently myocardial reperfusion with p-PCI is the 
best treatment strategy for STEMI, However, 
myocardial perfusion at the cellular level remains 
impaired despite removal of coronary obstruction in 
up to 50% of STEMI patients Several methods have 
been evaluated to improve reperfusion, including 
heart rate reduction, aspiration thrombectomy and 
several pharmacological approaches, such as 
glycoprotein platelet inhibitors, adenosine and drugs 
able to dilate the microcirculation, seem to be most 
effective when locally delivered through IC injection, 
probably because this results in an increased drug 
bioavailability in the area at risk.