Mitral regurgitation (MR) is a cardiac medical 
condition characterized by leakage of blood from
the left ventricle to the left atrium during systole 
due to the incomplete closure of the mitral valve.
MitraClip and PASCAL are innovative 
transcatheter edge-to-edge repair (TEER) devices
used to treat MR. Whether MitraClip or PASCAL
is better for achieving the best MR repair is still
controversial. In the present meta-analysis, we
aim to comprehensively compare both TEER 
device syste ms in severe MR patients and 
reveal which system is better depending on both
efficacy and safety outcomes.