A pot experiment was carried out in the glasshouse of National Research Centre, Giza Dokki, Egypt during two successive seasons 2020 and 2022 to examine the influence of proline spraying treatments on irrigation by saline water on Agave growth parameters and chemical contents, in three sprays at concentrations (0, 100 and 200 ppm) and salt stress (0, 5000, 10000 and 20000 ppm) with the control. However, the highest value of these characters (plant height, leaves number, leaf area, fresh weight/plant and dry weight/plant) obtained at up 100 ppm proline while (shoots and roots elongation and shoot and root fresh weights) were showed the highest increments by 5000 ppm salt irrigation, as well as the lowest values of carbohydrate % (0.39, 89.77, 19.78 and 314.44) resulted from the highest-level salinity by 15000 ppm with insignificant difference in flowering, and chemical characters. In addition, the proline treatments showed insignificant effect. It caused an increase in previous vegetative measurements and chemical constituents such as osmotic pressure, protein % and electrical conductivity analysis at 100 and 200 ppm compared with control. The purpose of study is to know more about the effects of proline and salinity stress on plant development and chemical components.