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Unraveling the Mysteries of Bipolar Mania: A Comprehensive Review

Article

Last updated: 05 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Pharmacology, Toxicology, and Biochemistry.

Abstract

Bipolar disorder is a mental health condition characterized by extreme mood swings, which include periods of mania. Mania is defined as an elevated or irritable mood lasting at least one week, potentially severe enough to require hospitalization. Symptoms of mania encompass impulsivity, risk-taking behavior, restlessness, grandiosity, racing thoughts, decreased need for sleep, increased productivity, and impaired judgment1. In bipolar mania, the presence of psychotic symptoms is highest during acute episodes. These symptoms can include delusions or hallucinations, and their occurrence is often assumed to reflect greater disease severity. However, recent studies suggest that while psychotic symptoms in bipolar manic episodes are associated with male gender and younger age, they may not be directly linked to other indirect measures of illness severity, such as the length of hospital stay or the need for long-acting injectable antipsychotics2. Furthermore, the relationship between mania and depression in bipolar disorder is complex. Depressive symptoms can occur during manic episodes, known as mixed features, and are associated with a more challenging course of the disorder. This includes a younger age at onset, more frequent and longer episodes, and increased risk of suicidality and substance abuse comorbidity3. Understanding the nuances of bipolar mania, including its association with psychotic and depressive symptoms, is crucial for effective treatment and management of the condition. This abstract provides a brief overview of bipolar mania, highlighting the clinical significance of psychotic symptoms and the intricate interplay between mania and depression within the bipolar spectrum.

DOI

10.21608/jpsdm.2024.290306.1017

Keywords

Psychotic, symptoms, depressive

Authors

First Name

Marc

Last Name

Khaled

MiddleName

-

Affiliation

College of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), Giza, Egypt

Email

200013027@must.edu.eg

City

-

Orcid

-

First Name

Ali

Last Name

Mohy Eldeen

MiddleName

-

Affiliation

College of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), Giza, Egypt

Email

200016079@must.edu.eg

City

-

Orcid

-

First Name

Mariam

Last Name

Waleed

MiddleName

-

Affiliation

College of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), Giza, Egypt

Email

92221@must.edu.eg

City

-

Orcid

-

First Name

Nour

Last Name

Mohamed

MiddleName

-

Affiliation

College of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), Giza, Egypt

Email

97684@must.edu.eg

City

-

Orcid

-

First Name

Yomna

Last Name

Omar

MiddleName

M

Affiliation

College of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), Giza, Egypt

Email

yomna5095@gmail.com

City

-

Orcid

-

First Name

Safaa

Last Name

Ayman

MiddleName

-

Affiliation

College of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), Giza, Egypt

Email

92169@must.edu.eg

City

-

Orcid

-

First Name

Norhan

Last Name

Ashraf

MiddleName

-

Affiliation

College of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), Giza, Egypt

Email

ashrafnora91@gmail.com

City

-

Orcid

-

First Name

Layla

Last Name

Ehab

MiddleName

-

Affiliation

College of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), Giza, Egypt

Email

200030815@must.edu.eg

City

-

Orcid

-

First Name

Amira

Last Name

Atef

MiddleName

-

Affiliation

College of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), Giza, Egypt

Email

miraatef155@gmail.com

City

-

Orcid

-

First Name

Nada

Last Name

Mamdouh

MiddleName

-

Affiliation

College of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), Giza, Egypt

Email

nadamamdouh20044@gmail.com

City

-

Orcid

-

First Name

Heba

Last Name

Raef

MiddleName

-

Affiliation

Department of Pharmacology and Toxicology, College of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), 12585, Giza, Egypt

Email

heba.ramdan@must.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Fahmy

MiddleName

Ibrahim

Affiliation

Department pf Pharmacology and Toxicology, College of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), 12585, Giza, Egypt

Email

mohamed.aljawaly@must.edu.eg

City

Cairo

Orcid

0000-0003-3660-3981

Volume

1

Article Issue

2

Related Issue

46902

Issue Date

2024-06-01

Receive Date

2024-05-17

Publish Date

2024-06-01

Page Start

98

Page End

108

Print ISSN

3009-6553

Online ISSN

3009-6677

Article File

JPSDM_Volume 1_Issue 2_Pages 98-108.pdf

PDF . 644.1kB

Link

https://jpsdm.journals.ekb.eg/article_357628.html

Detail API

https://jpsdm.journals.ekb.eg/service?article_code=357628

Order

357,628

Type

Review Articles.

Type Code

2,974

Publication Type

Journal

Publication Title

Journal of Pharmaceutical Sciences and Drug Manufacturing-Misr University for Science and Technology

Publication Link

https://jpsdm.journals.ekb.eg/

MainTitle

Unraveling the Mysteries of Bipolar Mania: A Comprehensive Review

Details

Type

Article

Created At

20 Dec 2024