Numerous biological effects of pomegranate fruit (Punica granatum Linn.) have been found. This fruit's juice has been shown to be a significant source of high concentrations of phyto-constituents. It is rich in antioxidants and polyphenolic compounds, including punicalagins, anthocyanins, and hydrolysable tannins, which have numerous nutritional and health benefits. This study examined the effects of 400 mg/kg/day of pomegranate peel ethyl acetate extract (PGE) on heart rate and blood pressure in Wister rats with fludrocortisone-induced hypertension. Vascular reactivity studies were conducted in segments of the aorta from normal rats, hypertensive control rats, and hypertensive rats treated with PGE. PGE treatment was found to significantly lower blood pressure in hypertensive rats treated with fludrocortisone salt; however, it had no effect on the mean blood pressure or heart rate in normotensive rats. PGE therapy considerably significantly decreased the hypertensive rats' isolated aortic strip's contractile responses to noradrenalin. This study will continue to separate the bioactive compounds and to design natural active formulas.