Colchicine is primarily used to treat gout, but it can also be used to treat other inflammatory diseases, such as familial Mediterranean fever (FMF). It was initially granted FDA approval in 2009 for the prevention of acute attacks and treatment of them, following a critical trial that demonstrated the medication's effectiveness. Excretion of colchicine and its metabolites occurs via the biliary and urine systems.
Several analytical methods used in the present literature to quantify are gathered and discussed in this systematic study which include UV-visible spectroscopy, spectrofluorimetry, electrochemical methods, and other chromatographic techniques such as HPLC, TLC and capillary electrophoresis. This work investigates the comparative application of several analytical techniques to determine colchicine. The information provided in this review study may be used to effectively carry out additional analytical research for quantitative determination of colchicine in crude drug, pharmaceutical dosage forms and biological fluids.
Keywords: Analytical approaches, Colchicine, osteoarthritis, gout.