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338568

Review: Pyrimidine Derivatives as Anticancer Agents

Article

Last updated: 29 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Organic, Analytical and Pharmaceutical Chemistry.

Abstract

Cancer is a disease that can be fatal everywhere. It can start in almost any organ or tissue of the body when abnormal cells grow uncontrollably; they go further than their usual boundaries to attack contiguous parts of the body and/or slap-up meal to other organs. The primary problem facing current treatment techniques, such as chemotherapy and radiation, is multidrug resistance (MDR). Finding a unique and varied structural framework could open the door to the creation of fresh, potent anticancer medications. Also, the knowledge in genomics and molecular sciences has helped in creating new drug targets. Pyrimidines, a class of nitrogen-containing heterocyclic compounds, play a significant role in crafting cancer treatment drugs. These synthetic compounds have proven effective against various cancers, including myeloid leukemia, breast cancer, liver cancer, pancreatic cancer, and idiopathic pulmonary fibrosis. This review presents the findings of several investigations conducted between 2006 and 2023 on pyrimidine derivatives and their corresponding anticancer characteristics.

DOI

10.21608/jpsdm.2024.257501.1010

Keywords

pyrimidine derivatives, Synthesis, Cancer agents, Chemotherapy

Authors

First Name

Amira

Last Name

Helwa

MiddleName

Atef

Affiliation

Department Pharmaceutical Organic Chemistry, College of Pharmaceutical Science & Drug Manufacturing, Misr University for Science and Technology (MUST), Al-Motamayez District, 6th of the October City 77, Egypt

Email

amira.helwa@must.edu.eg

City

-

Orcid

0000-0002-3330-476X

First Name

Noha

Last Name

Ryad

MiddleName

M.

Affiliation

Department of Pharmaceutical Organic Chemistry, College of Pharmaceutical Science & Drug Manufacturing, Misr University for Science and Technology t

Email

noha.gabr@must.edu.eg

City

-

Orcid

0000-0001-8813-5185

First Name

Amira

Last Name

Youssef

MiddleName

-

Affiliation

Department Pharmaceutical Organic Chemistry, College of Pharmaceutical Science & Drug Manufacturing, Misr University for Science and Technology (MUST), Al-Motamayez District, 6th of the October City 77, Egypt

Email

amira.youssef@must.edu.eg

City

-

Orcid

0000-0001-9069-9107

First Name

Yomna

Last Name

Omar

MiddleName

M.

Affiliation

Department of Pharmaceutical Organic Chemistry, College of Pharmaceutical Science & Drug Manufacturing, Misr University for Science and Technology

Email

yomna5095@gmail.com

City

-

Orcid

-

First Name

Khadiga

Last Name

Attia

MiddleName

M.

Affiliation

Department Pharmaceutical Organic Chemistry, College of Pharmaceutical Science & Drug Manufacturing, Misr University for Science and Technology (MUST), Al-Motamayez District, 6th of the October City 77, Egypt

Email

khadeja.attia@must.edu.eg

City

-

Orcid

-

First Name

Abd-Allah

Last Name

El Etrawy

MiddleName

S.

Affiliation

Department Pharmaceutical Organic Chemistry, College of Pharmaceutical Science & Drug Manufacturing, Misr University for Science and Technology (MUST), Al-Motamayez District, 6th of the October City 77, Egypt

Email

abdallah.etrawy@must.edu.eg

City

6th of the October City

Orcid

0000-0001-6160-798X

Volume

1

Article Issue

1

Related Issue

45797

Issue Date

2024-01-01

Receive Date

2023-12-23

Publish Date

2024-01-01

Page Start

54

Page End

68

Print ISSN

3009-6553

Online ISSN

3009-6677

Article File

JPSDM_Volume 1_Issue 1_Pages 54-68.pdf

PDF . 3.1MB

Link

https://jpsdm.journals.ekb.eg/article_338568.html

Detail API

https://jpsdm.journals.ekb.eg/service?article_code=338568

Order

338,568

Type

Review Articles.

Type Code

2,974

Publication Type

Journal

Publication Title

Journal of Pharmaceutical Sciences and Drug Manufacturing-Misr University for Science and Technology

Publication Link

https://jpsdm.journals.ekb.eg/

MainTitle

Review: Pyrimidine Derivatives as Anticancer Agents

Details

Type

Article

Created At

20 Dec 2024