Beta
ManageSearchChatDiscover
337388

Advances in Understanding and Treating Multiple Sclerosis: A Comprehensive Review

Article

Last updated: 29 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Pharmacology, Toxicology, and Biochemistry.

Abstract

Introduction: Multiple sclerosis (MS) is an autoimmune disease resulting in neurodegeneration accompanied by chronic inflammatory response, apoptosis and neuronal loss. It is characterized by number of signs including paresthesia, spastic paralysis, cognitive impairment, and functional deficits. More than 2 million people worldwide suffering from the disease. The generation and development of MS are heterogeneous and manifold. Aim and concept of review: The aim of this review is to provide detailed information about the pathophysiology, different treatments and protective agents as well animal models used for studying multiple sclerosis in pharmacological experiments. Furthermore, the review sheds light on the molecular mechanisms involved in the pathogenesis of the disease including infiltration of immune cells and expression of inflammatory and oxidative biomarkers that represent a significant indication of the disease. Conclusion: The review concluded with the potential therapeutic and neuroprotective approaches of management of multiple sclerosis. It provides future perspective concerning with controlling the incidence of multiple sclerosis.

DOI

10.21608/jpsdm.2024.257173.1006

Keywords

Multiple sclerosis, Inflammatory, apoptosis, Neurodegeneration

Authors

First Name

Eman

Last Name

Mohamed

MiddleName

-

Affiliation

Faculty of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), Giza, Egypt

Email

200013030@must.edu.eg

City

-

Orcid

-

First Name

Fatma

Last Name

yasser

MiddleName

-

Affiliation

Faculty of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), Giza, Egypt

Email

200013020@must.edu.eg

City

-

Orcid

-

First Name

hagar

Last Name

Hagag

MiddleName

-

Affiliation

Faculty of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), Giza, Egypt

Email

200013043@must.edu.eg

City

-

Orcid

-

First Name

juli

Last Name

wageeh

MiddleName

-

Affiliation

Faculty of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), Giza, Egypt

Email

200013059@must.edu.eg

City

-

Orcid

-

First Name

Marc

Last Name

Khaled

MiddleName

-

Affiliation

Faculty of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), Giza, Egypt

Email

200013027@must.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Ashraf

MiddleName

-

Affiliation

Faculty of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), Giza, Egypt

Email

200013029@must.edu.eg

City

-

Orcid

-

First Name

Norhan

Last Name

Yahia

MiddleName

-

Affiliation

Faculty of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), Giza, Egypt

Email

200013040@must.edu.eg

City

-

Orcid

-

First Name

Omnia

Last Name

Gamal

MiddleName

-

Affiliation

Faculty of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), Giza, Egypt

Email

200013046@must.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Fahmy

MiddleName

Ibrahim

Affiliation

Department pf Pharmacology and Toxicology, faculty of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology (MUST), 12585, Giza, Egypt

Email

mohamed.aljawaly@must.edu.eg

City

Cairo

Orcid

0000-0003-3660-3981

Volume

1

Article Issue

1

Related Issue

45797

Issue Date

2024-01-01

Receive Date

2023-12-21

Publish Date

2024-01-01

Page Start

21

Page End

30

Print ISSN

3009-6553

Online ISSN

3009-6677

Article File

JPSDM_Volume 1_Issue 1_Pages 21-30.pdf

PDF . 1.5MB

Link

https://jpsdm.journals.ekb.eg/article_337388.html

Detail API

https://jpsdm.journals.ekb.eg/service?article_code=337388

Order

337,388

Type

Review Articles.

Type Code

2,974

Publication Type

Journal

Publication Title

Journal of Pharmaceutical Sciences and Drug Manufacturing-Misr University for Science and Technology

Publication Link

https://jpsdm.journals.ekb.eg/

MainTitle

Advances in Understanding and Treating Multiple Sclerosis: A Comprehensive Review

Details

Type

Article

Created At

20 Dec 2024