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336728

Evaluation of the efficacy of camel milk lactoferrin nanoliposome against colorectal cancer

Article

Last updated: 20 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Food and dairy sciences
Nano technology

Abstract

Colorectal cancer (CRC) is a significant cause of death and cancer-related mortality worldwide. Lactoferrin (LF) is a promising molecule that was found to inhibit the growth of cancerous tumor.  This study explores the effect of camel milk lactoferrin nanoliposome (LFnl) on colorectal cancer (HTC-116 cells) as a potential therapeutic agent against colorectal cancer. The total purified camel milk LF concentration was 200 mg/l. Film hydration technique was used to produce LFnl. Advanced characterization revealed distinct nanoliposome shapes with a clear two-layered structure. The particle size ranged between 28.3 – 139 nm, and the zeta potential value was -22.6 mV. Exceptional encapsulation efficiency of 99.32% was achieved. The examination of HTC-116 cells and normal cells WI-38 elucidated an IC50 value of 40.5±0.9 µg/ml. while, the cytotoxicity assessments conducted on WI-38 cells exhibited a CC50 value of 43.5±0.3 µg/ml. This result indicated that LFnl should be used carefully when treated colorectal cancer.

DOI

10.21608/jpfs.2024.259780.1005

Keywords

camel milk, Lactoferrin, Nanoliposome, colorectal cancer

Authors

First Name

Sameh

Last Name

Hendy

MiddleName

Abdallah

Affiliation

Dairy Science Department, Faculty of Agriculture, Al-Azhar University, Cairo, Egypt.gypt

Email

samehhendy@azhar.edu.eg

City

Nasr City

Orcid

0009-0007-1492-8423

First Name

A.

Last Name

Gamal El Din

MiddleName

H.

Affiliation

Dairy Science Department, Faculty of Agriculture, Al-Azhar University, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Ezzat

Last Name

Abdel Fatah

MiddleName

Ahmed

Affiliation

Dairy Science Department, Faculty of Agriculture, Al-Azhar University, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Wafaa

Last Name

Salama

MiddleName

M.

Affiliation

Dairy Res. Dept., Food Technology Research Institute, Agriculture Research Center, Giza, Egypt.

Email

-

City

-

Orcid

-

First Name

Hosam El-Din

Last Name

Mostafa

MiddleName

-

Affiliation

National Institute of Laser Enhanced Sciences (NILES). Cairo University, Giza, Egypt.

Email

-

City

-

Orcid

-

First Name

Rania

Last Name

Azab

MiddleName

M.

Affiliation

National Institute of Laser Enhanced Sciences (NILES). Cairo University, Giza, Egypt.

Email

-

City

-

Orcid

-

First Name

Sameh

Last Name

Yacoub

MiddleName

S.

Affiliation

Faculty of Agriculture, Damanhour University, Damanhour, Egypt.

Email

-

City

-

Orcid

-

Volume

1

Article Issue

2

Related Issue

45286

Issue Date

2023-12-01

Receive Date

2023-11-06

Publish Date

2023-12-30

Page Start

45

Page End

57

Print ISSN

3009-7487

Online ISSN

3009-7886

Article File

JPFS_Volume 1_Issue 2_Pages 45-57.pdf

PDF . 680.1kB

Link

https://jpfs.journals.ekb.eg/article_336728.html

Detail API

http://journals.ekb.eg?_action=service&article_code=336728

Order

5

Type

Original Article

Type Code

2,955

Publication Type

Journal

Publication Title

Journal of Plant and Food Sciences

Publication Link

https://jpfs.journals.ekb.eg/

MainTitle

Evaluation of the efficacy of camel milk lactoferrin nanoliposome against colorectal cancer

Details

Type

Article

Created At

20 Dec 2024