Background: Polycystic ovarian syndrome (PCOS) is a frequent disease in 
women that affects their ability to reproduce, their metabolism, and their ability to 
control their androgen levels. It is brought on by an imbalance of female sex 
hormones as well as being aggravated by obesity. Purpose: To examine the effects 
of cryolipolysis on hormonal profile and menstrual regularity in obese women with 
PCOS. Methods: 50 female patients, aged from 18 to 30 years, were split into two 
groups of 25 patients each at random. Group A (control group), treated by a diet 
regime and aerobic exercise for 12 weeks; Group B (study group): treated by the 
same diet regime and aerobic exercise as Group A in addition to cryolipolysis for 
45 minutes per session, every 2 weeks for 12 weeks. Assessment of all females 
was carried out through measuring weight, body mass index (BMI), waist hip ratio, 
luteinizing hormone (LH), follicle-stimulating hormone (FSH), and insulin 
resistance (IR), in addition to menstrual regularity pre- and post-treatment.
Results: There was a significant improvement (P<0.05) in all measured variable 
after treatment compared to before treatment in both group A and B, by comparing 
post treatment values there is a significant difference (p<0.05) in all measured 
variable favouring the study group (group B). Conclusions: Cryolipolysis in 
addition to diet regime and aerobic exercise has significant effect on hormonal 
profile as well as menstrual regularity in obese women suffering from PCOS.