Background: Shoulder pain is a common problem in orthopedic clinics. The Rotator Cuff Quality of Life Index (RC-QOL) questionnaire covers pain, frequency, severity, symptoms, quality of life, and activities of daily living affected by shoulder disorders and has no Arabic version. Purpose: To find out the validity and reliability of the translated version of RC-QOL among the Arab population in Egypt. Methods: The questionnaire translated into Arabic according to recent guidelines by Tsang. Four experts panels and 340 patients with rotator cuff disorders (RCD) participated in this study. Test-retest was measured by interclass correlation (ICC) with confidence interval (CI) 95% and internal consistency analysis were measured by Cronbach's alpha value to test reliability. Face, content, and construct validity were evaluated for the RC-QOL. Factor analysis and internal construct validity were assessed, and convergent and divergent validity were tested by the correlation between RC-QOL, Disabilities of The Arm, Shoulder and Hand (DASH) and Western Ontario Shoulder Instability Index (WOSI) questionnaires. Results: The study showed that the scale index of clarity was 90% to 100% and the mean index of clarity was 98.82%, the item content validity index (CVI) ranged from 0.7 to 1, the scale CVI (S-CVI) was 0.97 (97%), the experts proportion of relevance ranged from 91.18 to 100% and the mean was 97.94%. The questionnaire items were filled out 100% on all sheets and it needed less than 13 min maximum and a minimum 3 min to be answered. Cronbach's alpha was 0.998, ICC was 0.928 to 0.953 with 95%. Conclusion: The Arabic version of the RC-QOL questionnaire is a reliable and valid tool to assess Rotator Cuff Disorder in the Egyptian population.