Background:  Knee OA is a highly prevalent chronic degenerative joint disease that causes significant disability. To the researcher's knowledge, local epidemiological studies of knee OA and patient characteristics of patients attending orthopedic outpatient clinics have not been carried out previously in Egypt. Purpose:  The present hospital-based record trial aimed to determine how prevalent knee OA is (and its features) in Kasr ALAiny (in Cairo) and Qalubiya (in Qalubiya) hospitals in Egypt. Methods: The physical therapy records of patients referred to orthopaedic outpatient clinics at these hospitals were reviewed from 1/1/2019 to 31/12/2019. Results: It was found that the one-year prevalence of knee OA ranged from 6.6% (107/1633) to 9.25% (151/1633 cases), based on including combined cases, patellofemoral OA, and arthroplasties or not. The male-to-female ratio was approximately 1:4.2. Most cases were affected unilaterally (37.75%), with more on the right side (25.2%). Knee OA was commonly combined with medial meniscal injuries (59%). Knee OA mainly affects females unilaterally (right more than left) and is commonly combined with medial meniscal injury. Conclusion:  Knee OA is prevalent among Egyptians. So, prophylactic measures should be taken by the stakeholders based on the determined features of knee OA.