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337869

Unveiling the secrets of oocyte activation, Is calcium the only solution?!: A mini-review

Article

Last updated: 20 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Embryology

Abstract

Total fertilization failure (TFF) refers to the complete inability of all oocytes in a human IVF cycle to undergo fertilization, even after the administration of intracytoplasmic sperm injection therapy (ICSI). Currently, oocyte activation insufficiency could explain the occurrence of TFF; however, its mechanism remains unclear. Calcium signaling plays a crucial role in oocyte activation events. Following fertilization, oocytes from humans and animals exhibited notable calcium oscillations. Abnormal calcium oscillations following fertilization could be the primary cause of TFF. Examining the literature revealed numerous attempts to investigate the primary cause and discover an effective solution for that alarming occurrence. The most commonly used regimen to overcome oocyte activation deficiency (OAD) is the addition of Calcium, which cannot induce the proper oscillation needed for fertilization. This literature review seeks to address the issue of fertilization failure (FF) by examining the various factors associated with this occurrence and investigating the available techniques for artificial oocyte activation following ICSI.

DOI

10.21608/jrme.2024.263227.1005

Keywords

Oocyte activation, sperm activation, Fertilization failure, ICSI, artificial activation

Authors

First Name

Nehal

Last Name

Adel

MiddleName

-

Affiliation

Madina ICSI Fertility Center, Madina women's hospital, Alexandria, Egypt. , Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt.

Email

nehal_adel83@hotmail.com

City

Alexandria

Orcid

0000-0002-2853-8334

First Name

Heba

Last Name

Maghraby

MiddleName

-

Affiliation

Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt. , Dar Alteb Infertility Center, Alexandria, Egypt.

Email

hebahali85@gmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Elmahdy

MiddleName

-

Affiliation

Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt. , Obstetrics and Gynecology Department, Faculty of Medicine, Alexandria University, Egypt.

Email

mahdy_moh@yahoo.com

City

-

Orcid

0000-0003-4332-9845

First Name

Dalal

Last Name

Guiziry

MiddleName

-

Affiliation

Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt. , Dar Alteb Infertility Center, Alexandria, Egypt., Clinical Pathology Department, Faculty of Faculty of Medicine Alexandria University, Egypt.

Email

efre.publications@gmail.com

City

-

Orcid

-

First Name

Hassan

Last Name

Maghraby*

MiddleName

-

Affiliation

Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt. , Dar Alteb Infertility Center, Alexandria, Egypt., Obstetrics and Gynecology Department, Faculty of Medicine, Alexandria University, Egypt.

Email

hassanmaghraby@gmail.com

City

-

Orcid

-

Volume

1

Article Issue

1

Related Issue

45864

Issue Date

2024-01-01

Receive Date

2024-01-16

Publish Date

2024-01-01

Page Start

32

Page End

41

Online ISSN

3009-7282

Article File

JRME_Volume 1_Issue 1_Pages 32-41.pdf

PDF . 362.6kB

Link

https://jrme.journals.ekb.eg/article_337869.html

Detail API

https://jrme.journals.ekb.eg/service?article_code=337869

Order

6

Type

Mini review

Type Code

3,010

Publication Type

Journal

Publication Title

Journal of Reproductive Medicine and Embryology

Publication Link

https://jrme.journals.ekb.eg/

MainTitle

Unveiling the secrets of oocyte activation, Is calcium the only solution?!: A mini-review

Details

Type

Article

Created At

20 Dec 2024