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338993

Global acceptance and rejection of COVID-19 vaccines: A systematic review and meta-analysis

Article

Last updated: 05 Jan 2025

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Subjects

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Tags

Hospital and Clinical Pharmacy

Abstract

A challengeable obstacle to the introduction of new vaccine that affects the transmission of certain infections is vaccine hesitancy, despite the availability of vaccines.
To assess the theoretical tendencies and public attitudes concerning the COVID-19 vaccinations.
PsycINFO, Science Direct, Embase, Scopus, EBSCO, MEDLINEcentral/PubMed, ProQuest, SciELO, SAGE, Web of Science, and Google Scholar were searched. All papers detailing rejection and acceptance of the COVID-19 vaccine were included with no language restriction. Abstracts, proposals, conferences, editorials, author responses, reviews, case reports & series, books, and studies with data not accurately extracted or overlapping data were excluded. A meta-analysis was conducted using the random effect model of the pooled proportion of vaccine acceptance and rejection using the meta-package of R software. Egger's regression test was performed to assess publication bias, and the quality of included studies was assessed using the Newcastle-Ottawa Scale.
Out of 12246 identified records, 36 articles were included in the quantitative analysis. The pooled proportion of COVID-19 vaccine rejection was 16% (95%CI:13-20, I2=100%), while that of COVID-19 vaccine acceptance was 65% (95% CI:60-70, I2=100%. Case-fatality ratio and geographical distribution represented the main determinants of vaccine acceptance. Vaccine acceptance increased by 27.17% (95% CI:3.46-50.88) for each 1% increase in case fatality (p<0.02). The acceptance increased in Africa by 1.86 (p=0.04) while the vaccine rejection decreased in Australia by 3.93(p<0.0001).
This meta-analysis demonstrated poor acceptance of COVID-19 vaccines, and the ratio of cases to fatalities had a profound effect on public perception of the vaccines. These findings should be used to inform relevant interventions for future pandemic responses.
PROSPERO registration-number:CRD42021232805

DOI

10.21608/japs.2024.249802.1003

Keywords

COVID-19 vaccines, Vaccine acceptance, Vaccine Hesitancy, vaccine rejection

Authors

First Name

Shaimaa

Last Name

Abdelmoneim

MiddleName

Abdelaziz

Affiliation

Clinical Research Administration, Alexandria Directorate of Health Affairs, Egyptian Ministry of Health

Email

mri.shaimaa.m.informatics18@alexu.edu.eg

City

Alexandria

Orcid

0000-0002-9197-6396

First Name

Dina

Last Name

Hafez

MiddleName

Mohamed Hanaa

Affiliation

Pharmacy Department, Alexandria University Students Hospital, Epidemiology Specialist, Alexandria University, Egypt

Email

dr.dina.biostat@gmail.com

City

Alexandria

Orcid

0000-0001-7244-0118

First Name

Iman

Last Name

Aboelsaad

MiddleName

Ahmed Fathalla

Affiliation

Department of Clinical Research, Maamora Chest Hospital , MoHP, Alexandria, Egypt

Email

mri.iman.m.informatics18@alexu.edu.eg

City

Alexandria

Orcid

0000-0002-9412-1668

First Name

Noha

Last Name

Hamdy

MiddleName

Alaa

Affiliation

Faculty of Pharmacy, Alexandria University,

Email

noha.alaaeldine@alexu.edu.eg

City

Alexandria

Orcid

0000-0002-4606-8567

First Name

Yasir

Last Name

Elhadi

MiddleName

Ahmed Mohammed

Affiliation

Department of Public Health, Medical Research office, Sudanese Medical Research Association, Khartoum, Sudan

Email

hiph.yelhadi@alexu.edu.eg

City

Khartoum

Orcid

0000-0003-3649-0374

First Name

Samar

Last Name

El-ganainy

MiddleName

Ossama

Affiliation

Department of Pharmacology & Therapeutics, Faculty of Pharmacy, Pharos University in Alexandria, Egypt

Email

samar.elganainy@pua.edu.eg

City

Alexandria

Orcid

0000-0002-4098-3078

First Name

Ehsan

Last Name

Deghidy

MiddleName

Akram

Affiliation

Biomedical Informatics and Medical Statistics Department , Medical Research Institute, Alexandria University, Egypt

Email

drehsan.deghidy@yahoo.com

City

Alexandria

Orcid

0000-0002-7584-8722

First Name

Ahmed

Last Name

Nour El-Deen

MiddleName

El-Sayed

Affiliation

Physiology Department, Faculty of Medicine, Al-Azhar University, Assuit, Egypt

Email

drnoor83@hotmail.com

City

Assuit

Orcid

0000-0002-8377-6255

First Name

Ehab

Last Name

Elrewany

MiddleName

Mohamed Adel

Affiliation

Tropical Health Department, High Institute of Public Health, Alexandria University

Email

ehabelrewany@alexu.edu.eg

City

Alexandria

Orcid

0000-0002-8700-0630

First Name

Alaa

Last Name

Khalil

MiddleName

Hamdy Taha

Affiliation

Oncology Physician, Cairo University Medical School, Egypt

Email

alaahamditaha@gmail.com

City

Cairo

Orcid

0000-0001-6527-4422

First Name

Karem

Last Name

Salem

MiddleName

Mohamed

Affiliation

Nephrology in Internal Medicine Department, Fayoum University, Egypt

Email

kariemsalem@gmail.com

City

Fayoum

Orcid

0000-0002-4963-7083

First Name

Samar

Last Name

kabeel

MiddleName

Galal

Affiliation

Clinical research department at Damietta Directorate for Health affairs, Ministry of Health and population, Egypt

Email

samar.kabeel@gmail.com

City

Damietta

Orcid

0000-0001-7509-090X

First Name

Ramy

Last Name

Shaaban

MiddleName

-

Affiliation

Department of Instructional Technology and Learning Sciences Utah State University, USA

Email

ramy.shaaban@usu.edu

City

Utah State

Orcid

0000-0003-1709-1036

First Name

Amr

Last Name

Alnagar

MiddleName

-

Affiliation

Department of general surgery, Faculty of Medicine, Alexandria University, Egypt

Email

amr.alnagar@alexmed.edu.eg

City

Alexandria

Orcid

0000-0003-3434-6459

First Name

Eman

Last Name

Fadel

MiddleName

Ahmad

Affiliation

Woman's Health and Midwifery Nursing, Faculty of Nursing, Mansoura University, Egypt

Email

e_a@mans.edu.eg

City

Mansoura

Orcid

0000-0002-7495-3491

First Name

Nagwa

Last Name

Elfeshawy

MiddleName

Ibrahim

Affiliation

Woman's Health and Midwifery Nursing, Faculty of Nursing, Mansoura University, Egypt

Email

nagwa_mostafa@mans.edu.eg

City

Mansoura

Orcid

0000-0001-8975-3663

First Name

Mohamed

Last Name

Tahoun

MiddleName

Mostafa

Affiliation

Department of Epidemiology, High Institute of Public Health, Alexandria University

Email

dr_tahoun@alexu.edu.eg

City

Alexandria

Orcid

0000-0001-7603-1549

First Name

Ziad

Last Name

El-Khatib

MiddleName

-

Affiliation

Universite du Quebec en Abitibi-Temiscamingue (UQAT) , Quebec, Canada

Email

ziad.khatib@gmail.com

City

Qu&eacute;bec

Orcid

0000-0002-0711-5404

First Name

Ramy

Last Name

Ghazy

MiddleName

Mohamed

Affiliation

Tropical Health Department, High Institute of Public Health, Alexandria University, Egypt

Email

ramy_ghazy@alexu.edu.eg

City

Alexandria

Orcid

0000-0001-7611-706X

Volume

1

Article Issue

1

Related Issue

45819

Issue Date

2024-01-01

Receive Date

2023-12-08

Publish Date

2024-01-01

Page Start

58

Page End

81

Online ISSN

3009-7061

Article File

JAPS_Volume 1_Issue 1_Pages 58-81.pdf

PDF . 800.0kB

Link

https://japs.journals.ekb.eg/article_338993.html

Detail API

https://japs.journals.ekb.eg/service?article_code=338993

Order

338,993

Type

Review Article

Type Code

2,921

Publication Type

Journal

Publication Title

Journal of Advanced Pharmaceutical Sciences

Publication Link

https://japs.journals.ekb.eg/

MainTitle

Global acceptance and rejection of COVID-19 vaccines: A systematic review and meta-analysis

Details

Type

Article

Created At

20 Dec 2024