335417

Extragonadal germ cell tumor presenting with spinal cord compression: a case report and literature review

Article

Last updated: 05 Jan 2025

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Abstract

Background
Yolk sac tumor or endodermal sinus tumor is an uncommon malignant germ cell neoplasm. This tumor usually presents in childhood or young adulthood as a testicular or ovarian mass. Extragonadal sites such as mediastinal, intracranial, and sacrococcygeal have been described. A review of the literature revealed limited related cases. The clinical presentation, radiographic characteristics, operative findings, and patient outcomes are discussed.
Case presentation
We report the occurrence of a primary paraspinal germ cell tumor in a 28-month-old boy who presented with thoracic spinal cord compression. The patient presented with pain, weakness, paraplegia, and bowel and bladder disturbances.
Conclusion
Extragonadal germ cell tumors presenting with spinal cord compression are rare; however, they should be included in the differential diagnosis of every child younger than 3 years old who does not present with the typical features. Germ cell tumors are sensitive to platinum-based chemotherapy, and surgery should only be performed for spinal cord compression and for obtaining tissue biopsy for a definitive diagnosis. The sooner the decompression is done, the better neurological outcome is achieved. Long-term remission, and possibly cure, can be achieved with a multidisciplinary treatment strategy.

DOI

10.1186/s43159-022-00173-4

Keywords

spinal cord compression, Germ cell tumor, Extragonadal germ cell tumor, Yolk sac tumor, Endodermal sinus tumor, Dumbbell-shaped tumor

Authors

First Name

Roula A.

Last Name

Farah

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Affiliation

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Email

dr.roulafarah@gmail.com

City

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Orcid

0000-0002-6392-1590

First Name

Judy K.

Last Name

Matta

MiddleName

-

Affiliation

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Email

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City

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Orcid

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First Name

Aida A.

Last Name

Metri

MiddleName

-

Affiliation

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Email

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City

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Orcid

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First Name

Noha A.

Last Name

Bejjani-Doueihy

MiddleName

-

Affiliation

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Email

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City

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Orcid

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First Name

Ibrahim C.

Last Name

Saikali

MiddleName

-

Affiliation

-

Email

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City

-

Orcid

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Volume

18

Article Issue

1

Related Issue

45425

Issue Date

2022-01-01

Receive Date

2022-03-09

Publish Date

2022-06-01

Print ISSN

1687-4137

Online ISSN

2090-5394

Link

https://apsj.journals.ekb.eg/article_335417.html

Detail API

https://apsj.journals.ekb.eg/service?article_code=335417

Order

335,417

Publication Type

Journal

Publication Title

Annals of Pediatric Surgery

Publication Link

https://apsj.journals.ekb.eg/

MainTitle

Extragonadal germ cell tumor presenting with spinal cord compression: a case report and literature review

Details

Type

Article

Created At

20 Dec 2024