This research was undertaken in the two seasons 2021/2022 and 2022/2023 at the Nursery of Ornamental Plants, Fac. Agric., Minia Univ., Egypt to examine the response of vegetative growth of Melissa officinalis, L. to compost (0, 4, 8 and 12 ton /feddan) and some antioxidants such as amino acids (1 and 2 ml/l) , seaweed extract (1.5 and 3 ml/l) and vitamin E (100 and 200 ppm) treatments. Data revealed that all vegetative growth (plant height, stem diameter, number of branches, leaf area and weights either fresh or dry were significantly increased with fertilizing plants with compost relative to control through the three cuts during both seasons. Moreover, all aforementioned parameters were increased from the first cut up to the third one except the plant height took the opposite trend. All treatments used of antioxidants significantly increased all above-mentioned parameters compared to the control through the three cuts during both seasons. Vitamin E at low concentration was superior in this concern. The best interaction treatment was to supplying plants with compost at 8 or 12 ton/fed and vitamin E at 100 ppm or sea algae at high concentration (3 ml/l).