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329781

The effects of OSAS corrective surgery and anesthesia on inflammatory and oxidative stress parameters in patients with obstructive sleep apnea syndrome

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Last updated: 05 Jan 2025

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Abstract

Introduction
Oxidative stress and airway inflammation are important in the pathophysiology of obstructive sleep apnea syndrome (OSAS).
Materials and method
The groups included 18 patients with an AHI below 5 (group 1), 28 patients with an AHI between 5 and 15 (group 2), 25 patients with an AHI between 15 and 30 (group 3), and 30 patients with an AHI of over 30 (group 4).
Results
The inter-group comparisons revealed differences in the 3rd measurement of leukocyte count and CRP value, in the 3rd and 4th measurements of HDL ( < 0.05). No significant difference was observed in the inter-group or intra-group comparisons for ARE, PON, and NT values ( > 0.05).
Conclusion
We observed that CRP, HDL PON, ARE, NT levels, and the leukocyte count were not related to the severity of OSAS in patients with OSAS. The difference observed in CRP and leukocyte count may be due to the continuous effect of the inflammatory effect of surgery in the early post-operative period. We thought that the increase in HDL in all groups after the 5th postoperative day was due to the surgical correction of airway obstruction. As a result, we concluded that CRP, HDL, PON, ARE, NT, and leukocyte levels are not markers for OSAS.

DOI

10.1186/s42077-022-00236-z

Keywords

Anesthesia, Inflammation, Obstructive Sleep Apnea Syndrome, Oxidative Stress

Authors

First Name

Ulku

Last Name

Ince

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-

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Email

uuulkuuu@hotmail.com

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Orcid

0000-0001-5517-1489

First Name

Hanife Karakaya

Last Name

Kabukcu

MiddleName

-

Affiliation

-

Email

-

City

-

Orcid

https://orcid.org/0000-0002-9626-139X

First Name

Aslı

Last Name

Bostanci

MiddleName

-

Affiliation

-

Email

-

City

-

Orcid

https://orcid.org/0000-0002-1535-2661

First Name

Sebahat

Last Name

Ozdem

MiddleName

-

Affiliation

-

Email

-

City

-

Orcid

https://orcid.org/0000-0002-0619-1405

First Name

Murat

Last Name

Turhan

MiddleName

-

Affiliation

-

Email

-

City

-

Orcid

https://orcid.org/0000-0003-3916-0944

First Name

Ikbal Ozen

Last Name

Kucukcetin

MiddleName

-

Affiliation

-

Email

-

City

-

Orcid

https://orcid.org/0000-0002-4541-013X

Volume

14

Article Issue

1

Related Issue

44741

Issue Date

2022-01-01

Receive Date

2022-03-23

Publish Date

2022-04-01

Print ISSN

1687-7934

Online ISSN

2090-925X

Link

https://asja.journals.ekb.eg/article_329781.html

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https://asja.journals.ekb.eg/service?article_code=329781

Order

329,781

Publication Type

Journal

Publication Title

Ain-Shams Journal of Anesthesiology

Publication Link

https://asja.journals.ekb.eg/

MainTitle

The effects of OSAS corrective surgery and anesthesia on inflammatory and oxidative stress parameters in patients with obstructive sleep apnea syndrome

Details

Type

Article

Created At

20 Dec 2024