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329755

Magnesium sulphate within multimodal analgesia, pre-emptive, or preventive analgesia

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Last updated: 05 Jan 2025

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Abstract

Background
Magnesium (Mg) is a non-competitive -methyl -aspartate receptor antagonist with antinociceptive effects. Multimodal therapy is the optimal strategy for perioperative pain control to minimize the need for opioids. Inflammation caused by tissue trauma or direct nerve injury is responsible for the perioperative pain. The concept of “pre-emptive” analgesia, analgesic strategies administered prior to the stimulus, can modify the peripheral and central nervous system processing of noxious stimuli, thereby reducing central sensitization, hyperalgesia, and allodynia remains controversial. A more encompassing approach to the reduction of postoperative pain is the concept of “preventive” analgesia. The purpose of the study is to detect the proper use of MgSO4 as an analgesic being a non-competitive -methyl -aspartate (NMDA).
Results
There is no statistically significant difference in the haemodynamic parameters, intraoperative (33% vs 20%) and postoperative requirement for analgesics 6.6% vs 10% among groups I and II, respectively. There is no significant difference in the numerical analogue scale, where 16 vs 17 patients with no pain, 12 vs 10 with mild pain, and 2 vs 3 with moderate pain in groups I and II, respectively.
Conclusion
The use of MgSO4 in a bolus with or without infusion is comparable in the control of intraoperative and postoperative pain.

DOI

10.1186/s42077-021-00210-1

Keywords

MgSO4, Analgesia, preventive, Pre-emptive

Authors

First Name

Walid Y.

Last Name

Kamel

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City

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Orcid

0000-0001-9573-3167

First Name

Aktham Adel

Last Name

Shoukry

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Volume

14

Article Issue

1

Related Issue

44741

Issue Date

2022-01-01

Receive Date

2021-12-29

Publish Date

2022-01-10

Print ISSN

1687-7934

Online ISSN

2090-925X

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https://asja.journals.ekb.eg/article_329755.html

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https://asja.journals.ekb.eg/service?article_code=329755

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329,755

Publication Type

Journal

Publication Title

Ain-Shams Journal of Anesthesiology

Publication Link

https://asja.journals.ekb.eg/

MainTitle

Magnesium sulphate within multimodal analgesia, pre-emptive, or preventive analgesia

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Article

Created At

20 Dec 2024