Helicobacter pylori (H. pylori) is a spiral shaped bacterium that lives and multiplies in the lining of the stomach, and it is a common cause of many stomach diseases. This study aims to show the effect of curcumin on helicobacter pylori in experimental rats .Sixty adult male albino rats,were randomly into six groups (10 rats each). as follows: Group (1): composed of normal rats as negative control groups(-ve), Group (2): composed of rats those were subjected to oral administration of at a dose (200 mg/kg/day) CAE. Group (3): composed of rats those were subjected to oral administration of at a dose (400 mg/kg/day) CAE.Group (4): composed of rats those were subjected to injection of (1mL/rat) twice daily) H. pylori act as a positive control(+ve).Group (5): comprise of rats infected by H. pylori those were treated oral with at a dose (200 mg/kg/day) CAE and Group (6): comprise of rats infected by H. pylori those were treated oral with at a dose (400 mg/kg/day) CAE, for six weeks . The results revealed that curcuma aqueous extract had 15 Phenolic constituents . Besides results indicated that the rats treated with CAE 200 and 400 mg/kg/day showed significantly decreased in serum cholesterol, triglycerides, glucose and LDL-C matched with a significant increase in serum HDL-C, In addition , at (p≤0.05) there were decreased ,serum ALT, AST, ALP, and GGT, Also, serum urea, creatinine, and uric acid levels, when compared with group (4), So this study recommended using curcumin in diets for its many benefits.