This study aimed to investigate the effect of magnetized and alkaline water on Ehrlich solid carcinoma (ESC) in mice. In addition to assess their antioxidant and anti-inflammatory activities. Twenty-eight CD1 mice were used, seven of them served as a control group (Gp1). The remaining mice were inoculation with Ehrlich ascites carcinoma (EAC) cells (2x10⁶/mouse). Then, EAC bearing mice were divided into three groups (7 mice/each), as follows; a positive control (Gp 2), drunk the magnetized water (Gp3), and drunk alkaline water (Gp4). The results showed that the magnetized water significantly improved the lipid profile, liver, and kidney functions compared to the positive control. On the other hand, alkaline water decreased the serum levels of total triglycerides and alanine transaminase. However, it increased the serum levels of total cholesterol, low-density lipoprotein cholesterol, and serum urea. Regarding antioxidant activity, both waters decreased malondialdehyde and carcinoembryonic antigen while increasing reduced glutathione. Additionally, magnetized water significantly increased superoxide dismutase, whereas alkaline has no effect compared to positive control. The results showed that both magnetized and alkaline water significantly decreased the volume of the Ehrlich tumor in mice.