This study evaluated the effects of inhaling kerosene and naphtha vapors on rats' respiratory systems. It included 30 male rats, divided into two separate investigations; in the first test, rats were exposed to Kerosene vapors for 6 hours each day for 30 and 45 days. In the second trial, rats were exposed to naphtha vapor for 6 hours each day, with differing durations of either 30 or 35 days. An investigation of lung tissues collected from male rats exposed to kerosene vapors for 30 days revealed vascular congestion, bleeding, and thickening of the walls separating the air sacs. Rats exposed to kerosene fumes for 45 days exhibited bleeding between pulmonary tissue and a modification of the typical structure of the alveoli. Lung histology in male rats exposed to 30 days of naphtha fumes showed interalveolar septal thickening and congestion within the lung tissue's blood vessels. Lung histopathology from male rats who inhaled naphtha vapors for 45 days revealed alveolar breakdown and bleeding in the lung tissues. Ultimately, the research concluded that inhaling kerosene and naphtha fumes alters the lung's histological structure and negatively influences the respiratory system.