Cisplatin (Cis) is a chemotherapeutic drug that has been used in the treatment of various types of cancers. However, the drug showed various toxic side effects on vital organs. This study aims to investigate the hepato-renal protective effect of Eremnia desertorum eggs powder (EDEP) in Ehrlich Ascites Carcinoma (EAC) bearing mice treated with Cis. Five groups of female Swiss albino mice were allotted as follows: Group (Gp1) served as a negative control, Gp2-Gp5 had inoculated intraperitoneally (i.p) with 1×10⁶ EAC cells/mouse. Then, Gp2 was left without treatment as a positive control (EAC-bearing mice).  After 24 hours, Gp3, and Gp4 had injected i.p. with Cis (2 mg/kg) EDEP (500 mg/kg) daily for 7 consecutive days, respectively. Gp5 was injected with a combination of Cis/EDEP as in Gp3 and Gp4. All treated groups were sacrificed at day 12, and the percentage of the body weight changes (%b.wt), tumor indices, haematological and biochemical parameters, and antioxidant /oxidant biomarkers as well as histological alterations of liver and kidney tissues were investigated. The results showed that the % b.wt changes were increased in EAC-bearing mice and EAC-bearing mice that were treated with EDEP. While, the treatment of EAC-bearing mice with Cis decreased the % b.wt changes. The treatment of EAC-bearing mice with a combination of Cis/EDEP led to an improvement in AST, ALT, urea, creatinine, antioxidant enzyme activities, and ameliorated the histopathological toxicities in the liver and kidneys in EAC-bearing mice.