There are times when it is challenging to stop chemotherapy side effects from happening when the patient is receiving treatment. Nowadays, the treatment with chemotherapy combinations is frequently utilized to treat different forms of cancer. The key benefit of utilizing numerous medications was thought to be the ability to lower dosages, which may result in decrease resistance and the maintenance of the same efficacy or, with a higher efficacy, or a synergistic impact. It has been suggested that pharmacological combinations consisting of natural products (NPs) and dietary supplements can have benefits comparable to those of traditional chemotherapy treatments, but with fewer side effects. Pre-clinical and clinical studies were carried out to evaluate how NPs worked against malignant cells. Thus, the optimal balance between potential side effects and anticancer activity is desperately needed. The therapeutic, chemo-sensitizing, and protective activities of NPs against malignant cells are covered in this review.