Applications of silver nanoparticles (AgNPs) include biosensing, cosmetics, and medicine. AgNPs may become deposited as particles in many tissues and vital organs after exposure. AgNPs toxicity could be removed from the body using natural products. This study aimed to address the effective of Phoenix dactylifera seed extract (PDSE) in treating renal and lipid profile alterations brought on by the exposure to AgNPs. The following four groups (n=10) of male CD1 mice were created: 200 µl of sterile saline has been injected intraperitoneal (i.p) into group 1 (Gp1). Gp2 had received PDSE (100 mg/kg) i.p. Gp3 had received 0.25 mg/Kg of AgNPs, i.p. every day for a month. Gp4 had received both AgNPs and PDSE treatment, as in Gp2 and Gp3. The kidney's histological changes and lipid profile were investigated. AgNPs caused a noticeable histological change in the kidney tissues as well as significant changes in the lipid profile. PDSE treatment after AgNPs injection reduced the toxicities on the kidneys` tissues and lipid profile. Together, PDSE treatment could be employed to decline the negative impacts that induced by AgNPs exposure on kidneys` tissues and lipid profile.