Cancer chemotherapy is an effective setting for treatments; however, it own severe side effects on vital organs. This study was conducted to evaluate the efficacy of Leiurus quinquestratus scorpion whole-body extract (LQWBE) as anticancer agent. Furthermore, the hepatic protective effect of LQWBE was evaluated. Forty female CD-1 mice were divided into four groups (n = 10). All groups were inoculated with 1x10⁶ EAC-cells/mouse. After 24 h of inoculation, group 1 (Gp1) left as EAC-bearing mice alone. Gp2 was injected with LQWBE (50 mg/Kg). Gp3 was injected with Cis (2 mg/Kg), while, Gp4 was injected with Cis/LQWBE as in Gp3 and Gp4. All injections were intraperitoneally (i.p), daily for 7 days. At day 14, the percentages of body weight changes (% b.wt), and tumor profile were determined. Hematological, biochemical, and histopathological investigations were assessed. The results showed that the effect of LQWBE had a moderate antitumor effect, however, provides a protective effect on hepatic tissues in EAC-bearing mice